Criteria for the identification of Endocrine Disrupting Chemicals

National and international governments are formulating legislation, policies, and regulations that include provisions for regulating the marketing and use of chemical substances including endocrine disruptors. But there are no formal scientific criteria for identifying substances with endocrine disrupting properties in the context of implementation of EDCs policies, legislation and regulation. This sections lists selected publications (reports, books, and peer-reviewed papers) on scientific criteria for identifying endocrine disruptors.


General reports on EDCs

American Chemistry Council. 2015. Contribution to the European Commission’s Public Consultation on defining criteria for identifying endocrine disruptors in the context of the implementation of the Plant Protection Product Regulation and Biocidal Products Regulation.

AOAC International. 2012. Appendix F: Guidelines for Standard Method Performance Requirements.

Center for Biological Diversity. 2010. Petition for Water Quality Criteria for Endocrine Disrupting Chemicals under Section 304 of the Clean Water Act, 33U.S.C. 1314. Presented before the US Environmental Protection Agency on January 11, 2010.

ClientEarth. 2013. REACH Registration and endocrine disrupting chemicals.

Collegium Ramazzini. 2013. Endocrine disrupting chemicals in the European Union.

Committee on the Environment, Public Health and Food Safety. 2013. EU Report on the protection of public health from endocrine disrupters (2012/2066(INI)). European Parliament 2012-2014, A7-0027/2013, PE496.297v04-00.

Danish Environmental Protection Agency. 2011. Establishment of Criteria for Endocrine Disruptors and Options for Regulation. Ministry of Environment, Chemicals: MST-621-00011.

De Belder, T. 2016. Substances for Screening Exercise on Endocrine Disruptors Published. Global Agricultural Information Network. GAIN Report Number: E16004. USDA Foreign Agricultural Service.

ENTRIX & Canada Ecotoxicity Testing and Screening, CETES. 2010. Endocrine Disruptor Screening and Assessment.

European Centre for Ecotoxicology and Toxicology of Chemicals, ECETOC. 2009. Guidance on Identifying Endocrine Disrupting Effects. Technical Report No. 106. ISBN: 0773-8072-106.

European Centre for Ecotoxicology and Toxicology of Chemicals, ECETOC. 2011. Risk Assessment of Chemicals. Workshop Report No. 21.

European Commission. 2014. Roadmap: Defining criteria for identifying Endocrine Disruptors in the context of the implementation of the Plant Protection Product Regulation and Biocidal Products Regulation.

European Commission. 2014. Report on public consultation on defining criteria for identifying endocrine disruptors in the context of the implementation of the Plant Protection Product Regulation and Biocidal Products Regulation.

European Food Safety Authority, EFSA. 2013. Scientific opinion on the hazard assessment of endocrine disruptors: scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment. EFSA Journal, 11(3) 3132.

European Crop Protection. 2016. Regulating Endocrine Disruptors: What are the key issues?

German Institute for Risk Assessment, BfR. 2016. Scientific principles for the identification of endocrine disrupting chemicals – a consensus statement. Outcome of an international expert meeting organized by the German Federal Institute for Risk Assessment.

Hass, U., Dalgaard, M., Jarfelt, K., Kledal, TSA. 2004. OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of Substances with Endocrine Disrupting properties. TermNord 2004:555. ISBN 92-893-1073-1.

Hazardous Substances Advisory Committee, HSAC. 2015. HSAC’s contribution to the European Commission public consultation on defining criteria for identifying endocrine disruptors in the context of the implementation of the plant protection regulation and biocidal products regulation. Responses by HSAC to the EU consultation on criteria for identifying endocrine disrupting chemicals (EDCs).

Horel, S. 2015. A toxic affair: how chemical lobbying blocked action on hormone disrupting chemicals. Corporate Europe Observatory.

Johnson, R., Wolf, J., Braubeck, T.  (Eds). 2009. OECD document for the diagnosis of endocrine-related histopathology of fish gonads. Draft of 7 January 2009. OECD.

Le Baron, M.J., Coady, K.K., O`Connor, J.C., Nabb, D.L., Markell, L.K., Snajdir, S., Marty, M.S. 2014. Key Learnings from Performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 In Vitro Assays. Birth Defects Research (Part B), 101:23-42.

Munn, S., van der Linden, S., Lostia, A. 2015. Methodology for evidence screening of chemicals in the context of impact assessment on criteria to identify endocrine disruptors. A PowerPoint presentation of the Joint Research Centre Methodology for evidence screening of chemicals at a technical meeting of EU Member States, Members of European Parliament, and other stakeholders, held on 6 November 2015 in Brussels.

Pesticide Action Network, PAN. 2015. Impact assessment Annex 1a.

Petersen, K., Linden B. 2014. Road to regulation of endocrine disruptors and combination effects. TermaNord 2014:529. Nordic Council of Ministers. ISBN: 978-92-893-2774-9.

Slama, R., Bourguignon, J., Demeneix, B., Ivell, R., Panzica, G., Kortenkamp, A., Zoella, T. 2016.. Environmental Health Perspectives, DOI: 10.1289/EHP217. National Institute of Environmental Health Services (NIEHS).

Tollefen, K.T., Scholz, S., Cronin, M.T., Edwards, S.W., Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A., Patlewicz, G. 2014. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). Regulatory Pharmacology and Toxicology, 70:629-640.

Toslov, J., Slothus, T., Christiansen, S. 2011. Endocrine Disrupters – Developing Criteria. TermaNord 2011:566. Council of Nordic Ministers. ISBN: 978-92-893-2237-9.

US Government. 2015. European Commission’s Public Consultation on Defining Criteria for Identifying Endocrine Disruptors (EDs) in the Context of the Implementation of the Plant Protection Product Regulation and Biocidal Products Regulation. Comments of the US Government.

Peer-reviewed articles on EDCs

Frische, T., Bachmann, J., Frein, D., Juffenholz, T., Kehrer, A., Klein, A., Maach, G., Stock, F., Stolzenberg, H., Thierbach, C., Water-Rohde, S. 2013. Identification, assessment and management of “endocrine disruptors” in wildlife in the EU substance legislation—Discussion paper from the German Federal Environment Agency (UBA). Toxicology Letters, 3(16):306-309.

Henriques, M., Cardoso, V.V., Rodrigues, A.M., Ferreira, E., Benoliel, M.J., Almeida, C.M.M. 2010. Simultaneous Determination of Ten Endocrine Hormone Disrupters in Water Using SPE/LC-(ESI)MS-MS. Journal of Water Resource and Protection, 2;818-829.

Lopez, Jacki. 2010. Endocrine-Disrupting Chemical Pollution: Why The EPA Should Regulate These Chemicals Under The Clean Water Act. Sustainable Development Law & Policy, 19-22:48-49.

Marx-Stoelting, Pfeil, R., Ritz, V. 2016. Science-based decision matrix for the identification of endocrine disruptors for regulation purposes. Journal of Consumer Protection, 11:203-208.

Marx-Stoelting, P., Niemann, L., Ritz, V., Ulbrich, B., Gall, A., Hirsch-Ernst, K.I., Pfeil, R., Solcki, R. 2014. Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties. Regulatory Toxicology and Pharmacology 70(3):690-604.

Websites on EDC

Ankley, G., Matthiessen, P., Ottinger, M.N., Van Der Kraak, G. 2014. SETAC focused topic meeting on endocrine disrupting chemicals: overview and outcomes. 15(5). SETAC GLOBE.

OECD. 2011. OECD Guidelines for Testing Chemicals, Section 2. ISBN: 9264122362.